Cytoscape Web
Click node...

Lacrimo-auriculo-dento-digital syndrome
1 OMIM reference -
3 associated genes
67 connected diseases
52 signs/symptoms
Disease Type of connection
Cutis gyrata - acanthosis nigricans - craniosynostosis
Saethre-Chotzen syndrome
Antley-Bixler syndrome
Apert syndrome
Aplasia of lacrimal and salivary glands
Crouzon disease
FGFR2-related bent bone dysplasia
Familial scaphocephaly syndrome, McGillivray type
Jackson-Weiss syndrome
Pfeiffer syndrome type 1
Pfeiffer syndrome type 2
Pfeiffer syndrome type 3
Achondroplasia
Camptodactyly - tall stature - scoliosis - hearing loss
Crouzon syndrome - acanthosis nigricans
Giant cell glioblastoma
Gliosarcoma
Hypochondroplasia
Isolated brachycephaly
Isolated cloverleaf skull syndrome
Isolated plagiocephaly
Muenke syndrome
Severe achondroplasia - developmental delay - acanthosis nigricans
Thanatophoric dysplasia type 1
Thanatophoric dysplasia type 2
Kallmann syndrome
Normosmic congenital hypogonadotropic hypogonadism
Multiple synostoses syndrome
Alobar holoprosencephaly
Lobar holoprosencephaly
Microform holoprosencephaly
Midline interhemispheric variant of holoprosencephaly
Semilobar holoprosencephaly
Septopreoptic holoprosencephaly
Autosomal dominant hyper-IgE syndrome
Deafness with labyrinthine aplasia, microtia, and microdontia
Oculootodental syndrome
Otodental syndrome
Autosomal dominant hypophosphatemic rickets
Hypercalcemic tumoral calcinosis
Distal 16p11.2 microdeletion syndrome
Proximal 16p11.2 microdeletion syndrome
Severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency
Autosomal agammaglobulinemia
SHORT syndrome
Chronic mucocutaneous candidiasis
Mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency
Susceptibility to viral and mycobacterial infections
Acute promyelocytic leukemia
Isolated NADH-CoQ reductase deficiency
Juvenile myelomonocytic leukemia
Laron syndrome with immunodeficiency
Monomelic amyotrophy
Noonan syndrome-like disorder with juvenile myelomonocytic leukemia
Pycnodysostosis
Early-onset autosomal dominant Alzheimer disease
Hereditary cerebral hemorrhage with amyloidosis, Arctic type
Hereditary cerebral hemorrhage with amyloidosis, Dutch type
Hereditary cerebral hemorrhage with amyloidosis, Flemish type
Hereditary cerebral hemorrhage with amyloidosis, Iowa type
Hereditary cerebral hemorrhage with amyloidosis, Italian type
Hereditary cerebral hemorrhage with amyloidosis, Piedmont type
Aldosterone-producing adenoma with seizures and neurological abnormalities
Obesity due to pro-opiomelanocortin deficiency
Sinoatrial node dysfunction and deafness
Diffuse cutaneous systemic sclerosis
Limited cutaneous systemic sclerosis
Synonym(s):
- LADD syndrome
- LARD syndrome
- Lacrimo-auriculo-radio-dental syndrome
- Levy-Hollister syndrome
Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare eye disease
- Rare genetic disease
- Rare odontologic disease
- Rare otorhinolaryngologic disease
- Rare skin disease
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: childhood
Average age of death: -
Type of inheritance: autosomal dominant
External references:
1 OMIM reference -
No MeSH references
Gene symbol UniProt reference OMIM reference
FGF10 O15520602115
FGFR2 P21802176943
FGFR3 P22607134934
Very frequent
- Autosomal dominant inheritance
- Broad / bifid thumb
- Chronic uveitis / blepharitis / episcleritis / scleritis / conjonctivitis / keratitis
- Clinodactyly of toes
- Complete / partial microdontia
- Conductive deafness / hearing loss
- Congenital alacrimia
- Defect / anomaly of lacrimal system
- Enamel anomaly
- External ear anomalies
- Fingerlike / triphalangeal thumb
- Folded helix
- Small / hypoplastic / adherent / absent ear lobe
- Tooth shape anomaly

Frequent
- Anodontia / oligodontia / hypodontia
- Anomaly / ectopia / hypoplasia / atresia of salivary glands / salivary duct
- Antihelix anomaly
- Broad / bifid big toe
- Clinodactyly of fifth finger
- Corneal ulceration / perforation
- Long / large / bulbous nose
- Low set ears / posteriorly rotated ears
- Mouth dryness / xerostomia
- Multiple caries
- Oral synechiae / abnormal frenulae
- Preaxial polydactyly (hand)
- Sensorineural deafness / hearing loss
- Syndactyly of fingers / interdigital palm
- Telecanthus / canthal dystopy
- Thumb anomalies (excluding hypoplasia)
- Visual loss / blindness / amblyopia

Occasional
- Agenesis / hypoplasia / aplasia of kidneys
- Branchial / posterior auricular / preauricular / cheek cysts / fistulae
- Broad forehead
- Choanal atresia
- Cleft lip and palate
- Deepset eyes / enophthalmos
- Gastroesophageal reflux / pyrosis / esophagitis / hiatal hernia / gastroparesia
- High forehead
- Hypospadias / epispadias / bent penis
- Large fontanelle / delayed fontanelle closure
- Micrognathia / retrognathia / micrognathism / retrognathism
- Nephrosclerosis
- Ptosis
- Radial club hand
- Radioulnar synostosis
- Radius anomaly / absence / agenesis / hypoplasia / abnormal radial ray
- Renal disease / nephropathy
- Rib structure anomalies
- Stillbirth / neonatal death
- Taurodontia
- Thumb hypoplasia / aplasia / absence